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| Ommati,L.V.M.; Rodrigues,C.A.; Silva,A.R.; Silva,L.P.; Chaufaille,M.L.L.F.; Oliveira,J.S.R.. |
| Allogeneic hematopoietic stem cell transplantation (AHSCT) is the treatment of choice for young patients with severe aplastic anemia (SAA). The association of antithymocyte globulin (ATG) and cyclophosphamide (CY) is the most frequently used conditioning regimen for this disease. We performed this retrospective study in order to compare the outcomes of HLA-matched sibling donor AHSCT in 41 patients with SAA receiving cyclophosphamide plus ATG (ATG-CY, N = 17) or cyclophosphamide plus busulfan (BU-CY, N = 24). The substitution of BU for ATG was motivated by the high cost of ATG. There were no differences in the clinical features between the two groups, including age, gender, cytomegalovirus status, ABO match, interval between diagnosis and transplant, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aplastic anemia; Allogeneic stem cell transplantation; Conditioning regimen; ATG-CY; BU-CY. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300005 |
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| Visentainer,J.E.L.; Lieber,S.R.; Persoli,L.B.L.; de Souza Lima,S.C.B.; Vigorito,A.C.; Aranha,F.J.P.; Eid,K.A.B.; Oliveira,G.B.; Miranda,E.C.M.; de Souza,C.A.. |
| The purpose of the present study was to evaluate the mixed lymphocyte culture as a predictive assay of acute and chronic graft-versus-host disease (GVHD). We studied 153 patients who received a first bone marrow transplantation from human leukocyte antigen-identical siblings. Acute GVHD was observed in 26 of 128 (20.3%) patients evaluated and chronic GVHD occurred in 60 of 114 (52.6%). One-way mixed lymphocyte culture (MLC) assays were performed by the standard method. MLC results are reported as the relative response (RR) from donor against patient cells. The responses ranged from -47.0 to 40.7%, with a median of 0.5%. The Kaplan-Meier probability of developing GVHD was determined for patients with positive and negative MLC. There was no significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mixed lymphocyte culture; Allogeneic stem cell transplantation; Chronic graft-versus-host disease. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500009 |
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